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A fundamental technical hurdle in systems neurophysiology has been to record the activity of individual neurons in situ while using microstimulation to activate inputs or outputs.
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This becomes evident if we consider an alternative scenario, in which activating inputs decrease over time.
Rather, multiple regions (containing one or more TFBSs) can each supply activating inputs to a gene's promoter 38, 39.
This discrepancy could be due to species-specific requirements for additional activating inputs, and/or silencing by species-specific repressors.
A potential solution to this problem is to add a step in the network expansion procedure: after introducing complementary nodes for all nodes with direct inhibitory effects, we enumerate all activating input-output paths with inhibitory edges separated by more than one activating edge and introduce the complementary nodes necessary for the maintenance of these paths in the extended network.
The remaining oscillator provided activating input for the other two oscillators.
mTORC1 complex is considered to be the major activating input that regulates cellular growth through downstream effectors S6K1 and 4EBP1 (eukaryotic initiation factor 4E binding protein 1) [ 23].
These findings point to a deficiency in the upstream activating input to Mst1/2 in HCC, and emphasise the importance of defining this regulation.
Increasing thresholds by integer values can have the same effect as node deletion when the number of activating (input) molecules is equal to the threshold.
We have presented evidence that, in the case of Mesp, this results in part from a change in an upstream activating input.
Its hand has sensors that generate small jolts of electricity to stimulate the same neural pathways that would activate with input from a typical human hand.
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CEO of Professional Science Editing for Scientists @ prosciediting.com