Sentence examples for activate inflammatory responses from inspiring English sources
To analyze whether human cathepsin B has the catalytic activity to produce bioactive IL-1β from pro-IL-1β to activate inflammatory responses in parenchymal cells (e.g., fibroblasts) such as caspase-1, we analyzed IκB degradation and NFκB phosphorylation in cells treated with pro-IL-1β after different processing.
Secondly, CPB itself might activate inflammatory responses [37].
Chemokines are small cytokines that direct migration of leukocytes, activate inflammatory responses and participate in tumor growth.
Of interest, structure-function studies revealed that the size and shape of the synthetic crystals influences their ability to activate inflammatory responses (e.g. nitric oxide, chemokine and cytokine mRNA) in vitro and in vivo.
This may be compared to naked DNA vaccines which typically express limited amounts of Ag largely restricted to inoculation sites, have restricted access to professional APCs, and poorly activate inflammatory responses, unless combined with additional genetic adjuvants [28].
Of interest, morphology-function studies reveal that the size and shape of the synthetic crystals (nanocrystalline, slow crystalline and rapid crystalline) influences their ability to activate inflammatory responses, as illustrated by differences in chemokine mRNA induction in vitro and in vivo and in the amplification of IFNγ-mediated NO production.
Recent in vitro results suggested that sulfatide can activate inflammatory response in microglia cells via activation of MAKPs and NF-κB [23].
They activate inflammatory response through several approaches.
Necrotic cells can release multiple pro-inflammatory factors, including high mobility group protein B1 (HMGB1) proteins, to activate inflammatory response.
Nie et al., have also demonstrated the capacity of GIP to activate inflammatory response and promote secretion of pro-inflammatory cytokines and chemokines in cell culture adipocytes [ 35].
Therefore, anticancer agents such as DNA-damaging agents enhance OXPHOS function causing elevation of mitochondrial ROS, which activate inflammatory response leading to mitochondria dysfunction and apoptosis.
