Both PTP and c-Src can be activated in the context of H/R, and the activation of c-Src in this context may therefore involve either direct oxidative activation or indirect activation as a consequence of PTP oxidation; this has not been tested yet.
In the case of excessive activation of this inhibitory network in the prefrontal cortex and in other interconnected neural structures activated in the context of persistent pain, the system might become dysregulated and even disrupted.
However, current understanding of how these pathways are activated in the context of developmental programming remains poorly defined.
This paper discusses the concept of the agINFRA project and presents its major outcomes, as adopted by existing initiatives activated in the context of agricultural research and education.
In the case a RCT will be activated in the context of the study, drugs compared in the RCT part of the study will be furnished by the Sponsor(s).
Additionally, Bar-Or et al. showed that B cells could exhibit abnormal proinflammatory cytokine responses (such as exaggerated production of TNF) when activated in the context of the Th1 cytokine IFN [ 37].
In evolutionary terms the responses that make up the defense cascade are primitive emotional states coordinated patterns of motor-autonomic-sensory response that are available to be automatically activated in the context of danger.
To test whether the 508 bp fragment of the DUSP6/ MKP- 3 promoter is appropriately activated in the context of a developing embryo, we placed this sequence into a reporter construct driving expression of destabilized EGFP (508ptkd2EGFP) [ 23].
When defense responses are activated in the context of therapy, therapists use a range of interventions, all building upon the therapeutic relationship, to help patients shift out of the given defense state and to return, eventually, to a state of calm.
It will be interesting to determine whether other EMT inducers are also activated in the context of this inflammatory microenvironment, which seems to be very likely, given that both TGF-β1 and hypoxia can induce the expression of Twist and Zeb transcription factors.
In particular, reversion of either T268A or F87V in P-I263F markedly reduces aziridination productivity (Table S2) and demonstrates some nonadditivity among the activating mutations (i.e., I263F is activating only in the context of T268A).
