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Under resting conditions the channels are closed but rapidly activate following a cytosolic Ca2+ increase (HS-YFP and short-circuit current assays).
Genome wide analysis of chromatin and DNA methylation profiles associated with genes that display this 'occlusion' (cis-mediated silencing or epigenetic memory) revealed a number of chromatin signatures that are clearly linked with genes that fail to activate following induction by cell fusion [ 60].
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However, the p16-pRB pathway may be activated following activation of, or independent to, the p21 pathway (24).
In addition, caspase-3-like activity was significantly activated following TNF-α treatment.
AKT becomes fully activated following PI3K activation and subsequent phosphorylation at the T308 and S473 regulatory sites.
These enzymes are upregulated and activated following enhanced neuronal activity and synaptic transmission [38] [40], and are involved in activity-dependent structural remodeling [39], [41].
Postsynaptic PKC is activated following strong NMDAR activation and release of Ca2+ from intracellular stores, experimentally achieved by stronger, repetitive LTP induction paradigms (Bliss & Collingridge, 1993; Raymond, 2007).
Following implantation, device therapy was chronically activated following a 2-week post-surgery recovery period.
Another report showed that NF-κB and AP-1 were activated following TPA-induced MMP-9 acthoughon though extracellular signal-regulated MAPK and PI3K/Akt [ 27, 37].
IKK activity assays reveal that IKK is activated following one hour of treatment with GO (Fig. 3D).
We hypothesized that MMP-2 and -9 would be activated following acute hindlimb ischemia (HI), and this activation would be temporally related to PMN infiltration.
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