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By sharing information on a more global scale, we can all activate faster, more coordinated and more effective responses.
Tyr 223 and Tyr 268 are on the SH3/SH2-linker interface, and the two mutants activate faster than wild-type Btk.
We hypothesized that the ability of the substrates to produce signal without inhibiting the target protease, coupled with an improved aqueous solubility, would create substrate analogues that activate faster and produce brighter signal in vivo compared to the original covalent probes.
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Moreover, a dedicated charge sensitive amplifier and analog filters are newly developed and tested here to optimize the performance of APDs to activate fast veto signals within a few μs from the BGO trigger.
Thus, ERK2 seems to activate fast genes in slow muscles, while its role in inhibiting slow genes remains more uncertain.
By contrast, transient expression of the Vp16 Prdm1 fusion protein was unable to rescue Prox1 expression or suppress myoblast fusion (Fig 2D,E), but was sufficient to activate fast-myosin expression.
However, while subcortical regions are activated faster and show short-lasting responses to light, cortical activity requires stronger and longer stimulations, as indicated in a study [12], in which 20 minutes of bright white light induced both thalamic and cortical modulations that steadily declined after light exposure albeit its rather lasting effects.
All nine humanitarian clusters were activated faster, within 48 h, and legitimate, whereas humanitarian clusters were clearly being led by government agencies and UN agencies/INGOs, as in contrast with the four clusters activation 1 week after the earthquake with unclear appointments of government agencies to become counterpart of the cluster's lead agency in West Java.
Monomeric Hv1 activates faster upon depolarization [8], while subunits in the dimer display cooperative behavior [33].
However, starvation-induced autophagy was activated faster in larvae lacking buffy.
Live-cell fluorescence imaging has shown that raft Akt is activated faster and more potently than non-raft Akt, presumably because of compartmentalization of various components of the signaling pathway, including the receptors, PI3K and Akt itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com