This is consistent with the possibility that centromere retention of the Aurora B kinase complex reengages the mitotic checkpoint in anaphase without activating error correction, possibly because of the kinetochore microtubule geometry at this time.
Cohesins are important to provide tension against bipolar spindle forces during prometaphase and the lack of tension activates error correction and the mitotic checkpoint at this stage of mitosis.
It can be hypothesized that the changes in brain activity among regular readers immediately following training are initially at the level of the stimulus perception, as their performance is basically automatic (see the amplitudes of the CRN component) and there is almost no need for them to activate the error detection monitoring system (as there is a low amount of errors).
Clip sequences that did not imply causality may have activated an error-detection mechanism and triggered event boundary perception processes.
PCNA thus modified activates the error-prone PRR pathway by recruiting translesion polymerases to the replication fork [21], [22].
In addition to the RCZ, the anterior insula is consistently activated during errors and other instances when performance monitoring becomes necessary (Klein et al. 2007).
To bypass lesions and complete replication, cells activate recombination-mediated (error-free) and translesion synthesis-mediated (error-prone) DNA damage tolerance pathways.
The development focus, as described in the following, was set especially on decreasing the error activating cantilevers by simply reducing the component sizes (compact design) and implementing an integral design consequently.
Furthermore, defects in homologous recombination activate alternative more error-prone mechanisms such as non-homologous end joining, presumably leading to genomic instability [ 11– 13].
According to this model, performance errors activate neurons in the inferior olive and their climbing fiber axons, which in turn trigger the induction of plasticity in the cerebellar cortex to produce adaptive changes in behavior (Marr, 1969; Albus, 1971).
