The phrase "activate death" is grammatically correct and can be used in written English.
It may be used in contexts related to gaming, programming, or metaphorical discussions about ending something.
Example: "To complete the final level, you must activate death to eliminate the enemy boss."
Alternatives: "trigger death" or "initiate death".
Thus, agents designed to selectively activate death receptor pathways may enhance the efficacy of conventional therapies and may even overcome some forms of cancer resistance.
Lexa, a humanized monoclonal antibody, specifically binds to DR5 to activate death signals and has a longer half life in vivo rendering it as a potential killer of tumor cells.
TRAIL and FasL are type II membrane proteins and activate death receptors for transduction of apoptotic signals.
The first one involves Ca(2+ -mediated expression of ligands that bind to and activate death receptors such as CD95 (Fas, APO-1).
Tumor necrosis factor (TNF)- α, TNF-related apoptosis-inducing ligand (TRAIL), and Fas ligand (FasL) can activate death receptor-mediated cell death.
This study could be helpful in designing novel therapeutic strategies in treating cancer by involving proteasomal inhibitors in combination with chemotherapeutic drugs that specifically activate death receptor-mediated killing.
It has been postulated that sustained JNK activation is required to activate death-promoting downstream targets such as Bim and Bak [ 41].
MADD encodes mitogen-activated protein kinase activating death domain, which interacted with tumor necrosis factor alpha receptor 1 to activate mitogen-activated protein kinase and propagate the apoptotic signal [22].
Apoptosis induced by c-Myc can be mediated through activation of the ARF-MDM2-p53 pathway, or by activating death receptors, such as CD95/Fas [33].
However, except for the P102LV, these mutants did not inhibit caspase activation, a step that is upstream of chromatin condensation in the Bax-activated death pathway.
We hypothesized that knockdown of map-kinase activating death domain containing protein (MADD), a TRAIL-resistance factor, may overcome TRAIL resistance in ovarian cancer cells.
