Sentence examples for activate compounds from inspiring English sources

This reversal in reactivity has been harnessed to activate compounds selectively under hypoxic conditions.

CYP1A1 is one of the main cytochrome P450 enzymes, examined extensively for its capacity to activate compounds with carcinogenic properties.

(B ) Structure-activity analysis of activating compounds.

Considering the tremendous potential of such compounds in addressing clinical drug resistance, it is important to define the minimum molecular signatures in defined cell models to pick up direct caspase activators from classical caspase-activating compounds.

In short, the bioassay used to measure the AhR mediated transactivity was based on the expression of the firefly luciferase in H4IIE.Luc cells resulting from the activation of the AhR pathway by AhR activating compounds.

Activating compounds for each Or were identified individually through activity thresholds, as described above.

Future studies may elucidate whether Ppar activation in tissues other than liver is important for the efficacy of SIRT1 activating compounds and what the relative contribution of specific Ppar family members is in a tissue-specific context.

SIRT1 activating compounds.

Boosting intracellular NAD+ levels by physiological (e.g. exercise, calorie restriction, fasting) or pharmacological [e.g. resveratrol, sirtuin activating compounds (STACs)] interventions, and inducing NAD+ biosynthesis through supplementation with precursors (e.g. NA, NAM, NR) or inhibition of NAD+ consuming enzymes (e.g. PARP-1, CD38) leads to activation of sirtuins (e.g. SIRT1, SIRT3).

A similar interaction between ATP and the activating compounds was observed for FRET1 (not shown).

Thus, determining the molecular events underlying differential signaling is essential for the design of selectively activating compounds.