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Opiates and exogenous cannabinoids, both potent analgesics used for the treatment of patients with neuropathic pain, bind to and activate class A G-protein-coupled receptors (GPCRs).
We used ephrinA2/Fc and ephrinB1/Fc to activate class A and B Eph receptors, respectively.
PACAP is a member of a family of neuropetides known to activate class II G-protein coupled receptors (GPCRs; reviewed in [ 54]).
The majority of tyrosine kinase coupled transmembrane receptors can activate class IA PI3K, although there is a clear variation in the strength and duration of the resulting signals [ 2].
In C. crescentus the ctrA gene belongs to class I which is known to activate class II flagellar genes, whose products are required for the expression of later flagellar genes [ 33].
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However, it is often difficult to selectively activate classes of afferents that subserve specific modalities using in vitro preparations.
The thiazolidinedione peroxisome proliferator-activated receptor-γ (PPAR-γ) activating class of drugs, such as troglitazone, rosiglitazone or pioglitazone, are insulin-sensitizing agents and are not generally considered for their effects on insulin secretion [ 82].
Connecting to the antenna's posterior side, JONs of class E are stretch-activated when the antennal is deflected backwards, whereas forward deflections stretch-activate class C and D JONs that mostly seem to connect to the antenna's anterior side [ 8,9,10].
Among activating class III receptor tyrosine kinase (Flt3) mutations, internal tandem duplications of Flt3 (Flt3-ITD) are detected in about 25% of patients with acute myeloid leukemia (AML).
Alkali silicate activated Class F fly ash slag blends containing fly ash as the major constituent (up to 70% by mass) are proportioned to develop sufficient mechanical properties under moist curing conditions.
GCCR and AR belong to a class of nuclear receptors called activated class I steroid receptors.
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