Exact(10)
The internal/external stimuli that activate Muse cells (prolonged treatment with proteolytic enzymes, lack of nutrients, low temperatures, hypoxia) are entirely different than those that activate cancer stem cells (ionizing radiation, ultraviolet radiation, chemical compounds, reactive oxygen species, error prone DNA repair, among others).
Elevated levels of DDB2, through its ability to activate cancer cell growth, may influence the effectiveness of anticancer drugs.
Both of these factors may activate cancer cells in the bone niche [ 25].
In peritoneal fluid, HB-EGF is sufficiently elevated to activate cancer cells even at an early stage of OVCA.
CMs can activate cancer cell death extrinsically, intrinsically, or both; therefore the mechanisms of CMs inducing cancer apoptotic cell death have been more diversified.
However, it is well established that persistent inflammation can activate cancer growth [ 8, 9], and in NSCLC, a prominent role for COX-2-derived lipid mediators has been postulated in this context [ 10, 11].
Similar(50)
Poor repair of these "double-strand breaks" can activate cancer-causing genes or inactivate tumor-suppressor genes.
The goal of most cancer immunotherapies is to activate cancer-specific T lymphocytes that can recognize and kill tumor cells expressing tumors-specific antigens.
Although it is clear that Reolysin possesses significant activity against Ras-activated cancer cells, the exact mechanisms of Reolysin-mediated cell death need further investigation.
We speculate that the activity of Fyn kinase is required for activating cancer cell growth on rigid fibronectin matrices.
Remarkably, the same enzyme activates cancer prodrugs that become cytotoxic only after two-electron reduction.
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