Exact(1)
In other words, in how far does the neighborhood of the small molecule, based on its targets, coincide with the pathways it is supposed to activate, based on the expression data of the experiment measuring its effects?
Similar(59)
The elevated appearance of p18 in the C62S variant of BAX in our experiments may be a result of an increased accessibility of BAX for the responsible protease, which is activated based on the cytotoxic activity of C62S BAX variant.
These plants are governed by the newly created New York State Independent System Operator and activated based on the free-market bids they submit to the operator.
When the ROM is low (as in a homophone), meanings tend to be selectively activated based on the context.
In our case, however, we favour the hypothesis that both ABCC8/V324M and ABCC8/W688R are mildly activating, based on the fact that W688R is associated with impaired glucose tolerance in the paternal grandmother.
In our analysis, we have inferred that DAF-16 is activated based on the behavior of the genes proposed as downstream targets of DAF-16 by Murphy et al.[ 25].
Since these signaling cascades may be differentially activated based on the binding specificity and affinity of various ligands to the receptor, RXR activation may not mimic the spectrum of changes that occur when PPAR-specific agonists are used to activate the heterodimer complex.
DOI: http://dx.doi.org/10.7554/eLife.06907.008 To determine the signaling pathways likely to be activated based on the differential RNA profiles, we performed Gene Set Enrichment Analysis (GSEA) (Subramanian et al., 2005) and observed that the most significant enrichment occurred for RNAs encoding downstream targets of oncogenic KRAS.
A handy "snooze" function on messages,is available too, which turns a message into a reminder you can activate based on when you arrive or leave a particular location.
Individuals and teams "activate" based on skill sets of volunteer and technical communities (VTCs).
The state of PC activation to APC was categorized as nonactivated, moderately activated or highly activated, based on maximum APC PCI values in relation to the normal range.
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