Sentence examples for activate alternative from inspiring English sources

These results support our model that the enhanced Fyn activity observed upon PAG suppression can activate alternative feedback mechanisms mediated by CTLA-4 and further supports the role of Fyn as a negative regulatory kinase in T-cell signaling [ 27].

With further genetic engineering these mutants may activate alternative hexoses as GDP-sugars for transfer to aglycones in vivo.

Ion transport modulators function to activate alternative chloride channels and/or to block sodium hyperabsorption that occurs through a dysregulated ENaC channel.

However, for samples where the density of dislocation sources has been reduced significantly by annealing, an additional strengthening mechanism, so-called dislocation source-limited hardening, may operate as a higher stress is required to activate alternative dislocation sources.

Due to the crosstalk among signaling pathways, cancer cells treated with a single target drug inevitably activate alternative pathways as escape mechanisms to overcome the blockage and therefore the effectiveness of these drugs.

Moreover, different cellular environments activate alternative promoters to different extents.

The current study has examined whether chronic DNA damage activates alternative pathways in DNA surveillance and repair activity and how deficiencies in DNA repair and telomere repair affect T-cell survival.

Experimental work with this model has established roles for B-cell-secreted autoantigenicomplexescomplexes in activating alternative complement, its subsequent association with C5aR and FcgRIII-mediated cell activation resulting in innate cell mediator activation and the production of inflammatory cytokine interleukin-1 and TNF-α, leading to joint destruction.

Another the group is considering is that hypoxia activates alternative ATP production pathways that help the organism function normally.

In contrast, PCa cells may acquire complete independence from AR signaling by activating alternative survival pathways, as exemplified by PC346DCC.

All therapeutic approaches that have been developed in the last few decades suffer from limited efficacy, due to the wide heterogeneity of tumors and to their ability to elude treatment by activating alternative developmental programs.