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These conditions, however, activate a range of stress response pathways to promote tumor survival and aggressiveness.
Since then, both HIF-1α and HIF-2α were detected in most human cells, and both activate a range of hypoxia response elements with similar efficacy.
Finally, AGEs are able to bind and activate a range of receptors, which then trigger a downstream cascade of pathogenic mediators.
Thus, the lung contains multiple cell types and exposure to LPS is known to activate a range of intracellular and extracellular pathways.
The most important oxygenase is CYP1A2, but also CYP1A1 and CYP1B1 can activate a range of arylamines to reactive intermediates [ 6].
This molecule binds to receptor proteins to activate a range of signaling processes that stimulate endothelial cells to become tip cells, and so encourage the formation of new sprouts.
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Plants are continuously subjected to pathogen attack and respond by activating a range of defense mechanisms.
Compared to multiplication problems, subtraction problems activated a range of areas in the frontal and parietal lobe, including the IPS, as well as the basal ganglia.
Furthermore, we note that a key event in the canonical Notch signalling pathway is the release, following ligand activation, of Notch intracellular domain (NICD) and its subsequent transport to the nucleus, where it activates a range of Notch pathway targets.
This is probably due to the fact that F/R activates a range of transcription factors to induce SOCS3 gene expression [8,9], through the activation of ERK and JNK MAP kinase pathways [8,9], whereas SOCS induction in response to 007 appears only to require induction of AP1 activity.
Both TNFR1 and TNFR2 activate a wide range of proinflammatory signal pathways, leading to activation of nuclear factor-kappa-B (NF-κB) and c-Jun N-terminal kinase, via recruitment of TNF receptor-associating factors (reviewed in [ 7]).
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