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In contrast, it has been shown that in the PNS, axons have a higher regenerative capacity as they activate a program leading to the activation of histone deacetylase 5 (HDand) and to a lower microtubule stability close to the injury site [ 5].
We posit instead that activated T cells committed to a central memory fate (TCM precursors) activate a program that enables the acquisition of central memory phenotype through the balancing effects of miR-150/miR-155, and self-renewal characteristics through a decrease expression of let-7 microRNAs, a shared trait between embryonic stem cells and central memory T cells.
Therefore, IRF8 may activate a program of gene expression that transforms microglia into a reactive phenotype.
Thus, Hox D3 may provide a switch to activate a program of angiogenesis.
The early vigorous inflammatory response appears to activate a program, subsequently leading to SIRS and, finally, MOF.
We have shown previously that TA and IXB activate a program of cell death in Arabidopsis cell suspensions [ 8] and in poplar (this work).
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Therefore, our findings suggest that IRF8 is not the sole transcription factor for microglial activation but rather activates a program of gene expression that determines signaling activity of reactive microglia, which provides a newly observed mechanism for microglial activation.
Mexican doctors activated a program to allay anxiety among staff members, offering the staff information, a hot line, psychological support and medical examinations.
On July 7, he told me, the department activated a program to help low-income residents stay connected to the city's water supply, financed with about a million dollars' worth of donations collected over the years through voluntary contributions from other customers.
Moreover, using an explant assay of pancreatic endocrine cell differentiation, we provide evidence that RA activates a program of cell differentiation that recapitulates the normal temporal program of β-cell differentiation.
We also provide evidence that RA induces the generation of Ngn3+ endocrine progenitor cells and stimulates their further differentiation into β-cells by activating a program of cell differentiation that recapitulates the normal temporal program of β-cell differentiation.
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