Sentence examples for activate a checkpoint from inspiring English sources
It has been reported that activation of Rad53 in response to telomere shortening still occurs in the absence of Rad9 and that Mrc1 is responsible for this activation in telomerase-deficient cells, in which telomeres continually shorten until they activate a checkpoint [23].
They activate a "checkpoint" to hold up the entire cycle until everything has been set right for renewed progress.
These data also suggest that if the stalled forks activate a checkpoint, this does not strongly downregulate replication initiation of other plasmid molecules in these experimental conditions.
This difference may simply reflect a limitation of the egg extract system or could, more interestingly, mean that Xenopus embryonic-like cell cycles lack the ability to activate a checkpoint in response to PIASγ-depletion.
This activates a checkpoint control, which signals the cell to undergo cell cycle arrest and initiate DNA repair.
DNA damage during S and G2 phases activates a checkpoint that is highly conversed from fission yeast to humans and higher plants [8], [9].
Activated ATM kinase activates a checkpoint response, including subsequent aggregation of DNA repair proteins, and phosphorylates a large number of substrates depending on the number of DSBs [17], [19], [20].
These results suggest that, while Swi3 mediates full activation of the replication checkpoint in response to stalled replication forks, Swi3 activates a checkpoint-independent pathway to facilitate recovery of collapsed replication forks and the establishment of sister chromatid cohesion.
Cells that escape the DNA damage checkpoint with poorly organized chromosomes might activate a mitotic checkpoint [ 7] and cause the accumulation of MDCs [ 5].
This suggests that the genetic defects in mitochondria activate a metabolic checkpoint, producing autophagy impairment and mitochondrial accumulation that limit tumor progression, revealing a novel tumor-suppressive mechanism for mitochondrial inhibition with metformin.
Do short telomeres activate a DNA checkpoint (G2/M arrest) response?
