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In addition, phosphoproteomic approaches can be exploited to monitor changes in phosphorylation events in order to characterize drug actions on cell signaling pathways and/or signaling cascades.
Furthermore, phosphoproteomic approaches can be exploited to monitor changes in phosphorylation events in order to characterize drug actions on cell signalling pathways and/or signalling cascades.
Other calcium binding genes exert their actions on cell adhesion.
The organized structure of the growth plate is tightly linked between the chondrocytes and the extracellular matrix (ECM) and Wnt actions on cell adhesion have been proposed [38].
Recently a spate of non-apoptotic caspase actions on cell proliferation and migration have been described that favor the recovery process [26] [28], [43], [44].
These data demonstrate shared mechanisms of action of AZA and DAC on DNA-mediated markers of activity, but distinctly different effects in their actions on cell viability, protein synthesis, cell cycle, and gene expression.
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Calcium ions are able to transmit diverse signals that exert primary actions on cells.
Hence, we focus on drugs (approved or in clinical development) with stimulatory actions on cells of the osteoblast lineage.
IL-1β is the prototypic inflammatory cytokine and has multiple actions on cells and tissues (reviewed in [ 23]).
EGFR has multifaceted actions on cells from a variety of tissues and is capable of regulating their proliferation, differentiation, survival, migration, and adhesion.
However, the CaSR has also been shown to have pleiotropic actions on cells, including modification of cellular proliferation, differentiation, and apoptosis [ 18– 20].
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