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This association is apparent with the interrelated actions of nuclear and mitochondrial transcription and translation of the mitochondrial electron transport chain.
One cycle involving both loops takes about 24 hours to be completed and is governed by post-translational modifications and may be modulated by the actions of nuclear receptor co-activators and co-repressors.
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A large part of the program also involves developing computer simulations of the action of nuclear explosives.
Two parallel lines of research were pursued: (1) development of technology to employ intercalation in the design of safe and effective chemicals, e.g. pharmaceuticals, nutraceuticals, agricultural chemicals; (2) exploration of intercalation in the mode of action of nuclear receptor proteins.
To investigate the action of nuclear factor (NF -κB iNF -κBomyosin adenomyosise the potentiandthevaluatec effecthef andrograpotentialn therapeuticsis factor (TNF)-α-induceffectressiof of NF-κB-mediandrographolideonxygease-2 (COX-2), vascular endotumoral growth factor (VEGF), anecrosise factor (TNF -α-inducedoTNF -α-inducedlls.
Mitochondrial function depends on the coordinate action of nuclear and mitochondrial genomes.
According to our model, this difference might largely be dependent on the action of nuclear phosphatases that affects more ERK1 because of its longer retention time in the nucleus.
Elements controlling IL-2 expression include the combined activation of TCR and co-stimulatory receptor [9], a certain threshold level of cytosolic Ca2+ [10]; [11], the cooperative action of nuclear factors of activated T cells (NFAT), NF-κB and AP-1 [12]–[14], chromatin remodeling [15]; [16], transcription [16], message stability [17], and translation [18].
These observations suggest that the action of nuclear Survivin in tumour cells may be tumour specific.
In summary, the above examples depict the variety of mechanisms of action of nuclear GFs and RTKs on the regulation of transcription.
These multiple thyroid hormone effects are largely mediated by the action of nuclear based thyroid hormone receptors (TR) the thyroid hormone receptor alpha and beta.
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