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HER2 is an important clinically actionable target, indicating this type of targeted sequencing analysis, which has greater sensitivity than exome sequencing and is applicable to formalin-fixed paraffin-embedded tissue, may soon aid in the management of patients when planning primary or secondary treatment regimes.
An important actionable target in NSCLC is the epidermal growth factor receptor (EGFR).
An actionable target was defined as a target associated with clinical benefit from the matching therapies.
More work is warranted to shed light on the role of this metabolic axis in cancer because of its potential as an actionable target for treatment [ 110, 111].
Overall, at least one (median, 5.5; range, 1 13) actionable target was identified for each patient (median, 5.5; range, 1 13).
Hence, the microbiome is now emerging as both a biomarker and an actionable target responding to dietary intervention in personalized medicine.
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The difficulty in defining gene copy number as a predictive biomarker for stratification of patients for targeted therapy is well recognized even with established actionable targets, such as HER2 in breast cancer.
Identifying new actionable targets will be essential to expand the benefits of targeted therapies to a broader range of patients.
And also you talked about actionable targets.
"We want actionable targets, not those that remain aspirational," Mohammed said.
The findings could raise the likelihood of finding actionable targets in individual patients with breast cancer.
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