Exact(5)
The effects of stimulus and action variability should therefore be carefully considered when designing and interpreting experiments involving multi-neuronal recordings.
We argue that the effects of either stimulus or action variability on the observed correlation, though generally ignored, can be substantial.
78 If one looks at GC action variability, one can distinguish between receptor level (i.e., at the GR) and prereceptor level action.
However, their use is limited by slow onset of action, variability of effect, frequent INR testing, and need for dosage adjustment.
These include that the action can be interpreted as efficiently related to an outcome, the presence of a choice or selection on the part of the agent, action variability and salient action effects (for further discussion see Hernik & Southgate, 2012).
Similar(55)
Stern, E. A., Kincaid, A. E. & Wilson, C. J. Spontaneous subthreshold membrane potential fluctuations and action potential variability of rat corticostriatal and striatal neurons in vivo.
The failure of clopidogrel to provide optimal protection may be related to delayed onset of action, interpatient variability in its effect, and an insufficient level of platelet inhibition.
Although the authors proposed the chelation of Ca2+ as the mechanism of action, the variability of reported potency with the peptide sequence hints at an alternative allosteric mechanism.
In addition, basal insulin analogs (glargine, detemir) have been reported to offer longer duration of action, less variability, more predictability, less hypoglycemia (especially nocturnal), and a favorable effect on weight.
Moreover, the degree of reliance on external visual feedback appeared to be associated with the reliability of internal sensorimotor information about the action: The variability of internal sensorimotor information in patients was approximately twice that of controls, and the influence of external visual feedback about the action in patients was about twice that of controls.
After implementing corrective actions the variability was reduced such that the level of Form 3 was within an acceptable range of ±1% w w−1 in fresh samples of API.
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