Sentence examples for action upstream from inspiring English sources

The lack of formal action upstream has long been maddening to the downstream states most affected by the pollution, and the extreme flooding this year has only increased the tensions.

Past findings have shown that IGF-1R mediates antiestrogen resistance through cross-talk with estrogen receptor (ER) signaling and via its action upstream of the epidermal growth factor receptor and human epidermal growth factor receptor 2. Yet, the direct role of IGF-1R signaling itself in antiestrogen resistance remains obscure.

We then discuss the regulation, cerebral actions, upstream modulators and downstream targets of Nrf2 pathway.

Prostaglandins biosynthesis depends on the sequential action of upstream cyclooxygenases (COX) and terminal synthases but no PGF2α synthases (PGFS) were functionally identified in mammalian cells.

The expression of Olig2 is likely repressed in undifferentiated cells through the concerted action of upstream repressive elements including the ULTRA and, possibly, two other regions [38].

In this respect, we now show that regulation of P-GSK3βTyr216 P-GSK3βTyr216ved by the dualevelson of upstreachievedes and phosphatases, is a possibye mechanism responsible for modulatheg GSK3 activity specifically in growth cones.

Our observations suggested that Yju3p complements the action of upstream lipases Tgl4p and Tgl3p in TAG and DAG hydrolysis and may also hydrolyze MAG derived from the degradation of phospholipids.

In particular, it is not clear what mechanism leads to the concentration of Plk4 at a specific site on the mother centriole surface and whether the choice of this site reflects a stochastic event or the action of upstream regulatory proteins.

Figure 4C demonstrates an increase in quinpirole bias toward β-arrestin in cells expressing additional GRK compared to β-arrestin in cells expressing normal levels of GRK, a result expected on the basis of mass action for upstream receptor/arrestin modulators.

As might be expected for a key regulatory enzymes that functions at the hub of many nuclear processes, PARP-1 is subject to the regulatory actions of upstream signaling pathways that can control PARP-1 activity and function.

BMP6 was not able to counteract this TPA-induced ERK response, which is in line with its proposed inhibitory actions further upstream at the level of TGF-β and Smad expression.