This suggests that inhibition of angiogenic targets (VEGFR and PDGFR) may not be the only mechanism of action that contributes to the clinical effects of sorafenib.
We postulate that it is this inversion of RhoA/Rac1 function, together with PI3K regulatory action, that contributes, in part, to the upregulation of NHE1 by serum deprivation in MDA-MB-435 cells, and hence to increased invasion and malignant progression.
He was dismissed as labour minister in 1954 because of his role (with the president's acquiescence) in radically doubling the minimum wage, an action that contributed greatly to the inflationary spiral.
Another action that contributed to the conspiracy, the charging documents say, was the circumvention of a methane monitor, which is attached to a continuous mining machine and shuts it down if methane levels rise.
Study of the complex mechanisms of action that contribute to the clinical efficacy of rituximab have led to novel clinical trials including novel combinations, schedules, and generation of additional antibodies designed to have even greater effect.
Although these standard agents have multifaceted mechanisms of action that contribute to their anticancer activity, both have been shown to stimulate ER stress.
The process showed how an increased awareness of gender inequities facilitated the emergence of values (respect and responsibility) and behavior (thoughtful action) that contributed to increase the informant's critical thinking and agency at individual, social, and political levels.
The process also shows how an increased awareness of gender inequities facilitated the emergence of values (respect and responsibility) and behavior (thoughtful action) that contributed to increase the informant's critical thinking and agency at an individual, social, and political level.
Motor learning is based on the concept that learning is a process resulting in the capability to perform skilled actions that contributes to relatively permanent changes in behaviour.
The organization, which partners with UNICEF and the U.N. Development program, seeks to elicit "small actions" that "contribute to shaping the world" by leading to "specific and tangible outcomes" that "generate real impact".
And while in a narrow sense Dr Kelly was responsible for his own death, it was not the BBC's actions that contributed to his disturbed state of mind, but the threats and bullying of the Ministry of Defence.
