Sentence examples for action specificity from inspiring English sources

Thus, the action specificity of artemisinins is achieved through the specific mitochondrial activation in the malarial parasites or yeast, whereas the damaging action of the resultant free radicals could be local and promiscuous.

While the discipline of Pharmacology taught us last century that inhibitor action specificity is dependent on the concentration used, these experiences have been ignored by users of siRNA technologies.

The six relevant cases are examined individually in the context of each of the main chapters of enzymology, i.e. as regards mechanism of action, specificity of substrate and isoenzyme, reversible and irreversible inhibition, and mutation of residues (enzyme evolution and enzyme engineering).

We suggest that fundamental differences among mitochondria from different species delineate the action specificity of this class of drugs, and differing from many other drugs, the action specificity of artemisinins originates from their activation mechanism.

In efforts to explore how the action specificity of artemisinin is achieved, we found strikingly rapid and dramatic reactive oxygen species (ROS) production is induced with artemisinin in isolated yeast and malarial but not mammalian mitochondria, and ROS scavengers can ameliorate the effects of artemisinin.

The gene product(s) must also be characterized for identity, structure, mode of action, specificity, toxicity, and allergenicity (Cockburn, 2001; Codex Alimentarius Commission, 2009; EFSA, 2008a; König et al., 2004).

This review describes how structural data, obtained in the last 3 4 years, have contributed to our understanding of the mechanisms of action and specificity of GTs.

This will give further insight into the exact mechanism of action and specificity of the compounds.

In addition, the autolytic activity displays a remarkably strong preference for cysteine in the P1 position, which is novel insight into the action and specificity of HtrA1 and explains the sensitivity toward the redox state of the surrounding environment.

and Ephestia kuehniella (Zeller), at the beginning of the 20th century [ 1, 2], Lepidoptera have served as the leading insect model for elucidating the mode of action and specificity of B. thuringiensis and its associated insecticidal toxins.

When assessing the toxicity pattern observed so far in the various clinical studies described, it is obvious that with regard to mechanism of action tumour specificity is most likely to be of critical importance.