Likewise, Bamfield (1994) examined a comparatively small sample of four action sites against one control site.
Herein, we design a two action sites strategy to break interdependence restriction to reduce the calculative overpotential.
Moreover, AMPs could be degraded or removed by the endogenous protease or secreted by organism before arriving at the action sites.
They easily pass through blood circulation system [27],[28] and then reach action sites faster without being hydrolyzed by digestive enzymes during the gastrointestinal digestion [29],[29].
However, efficient delivery of ASOs to their action sites with enough concentration remains a major obstacle, which greatly hampers their clinical application.
Nanoparticles with multi-therapeutic actions targeted to different action sites of target cell could more effectively reduce the blood/renal clearance, increase the tumor accumulation, and, more importantly, induce the apoptosis/death and inhibit the growth of cancer cells [3].
