Both azimilide and dofetilide increased monophasic action potential duration, cycle length of idioventricular rhythm, and QT-time.
Ranolazine also increased the action potential duration at any given pacing cycle length, which the authors mainly attributed to its additional effects on the main repolarizing K current IKr.
The last 10 action potentials of a train were averaged and used to measure the resting membrane potential, the action potential plateau height, and the action potential duration.
Vrest, resting potential; APA, action potential amplitude; AP threshold, action potential threshold; dV/dt, action potential rate of rise; APD 50, action potential duration at 50% of the maximal amplitude.
The action potential duration was evaluated at half-amplitude.
The smallest myocardial region capable of initiating a propagated action potential ("liminal length") is inversely related to the extra- and intracellular resistivities, which are largely dependent on interstitial fibrosis and electrical coupling between myocytes respectively [52] [53].
When a nerve fires, it sends an electrical signal called an action potential along its length.
By then plotting the locations of stimulation electrodes that successfully evoked somatic action potentials, continuous lengths and some branching of a neuron's arbour were partially reconstructed at 638 locations (Fig. 7a).
The duration of the action potential in ventricular cardiocytes determines the length of the QT interval in surface ECGs.
We show that ventricular myocytes isolated from FO-fed rabbits, relative to myocytes from control rabbits, had much more positive plateau heights and longer action potential durations tested at cycle lengths of 0.3 2 s.
The action potential that is conducted along the length of the muscle cell originates in a depolarization of the postsynaptic membrane of the neuromuscular junction caused by the release of acetylcholine from the presynaptic nerve terminal.
