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Previous studies revealed mechanisms of dendritic inputs leading to action potential initiation at the axon initial segment and backpropagation into the dendritic tree.
Exposure of TRPV1 receptors to high concentrations of capsaicin initially causes depolarization, action potential initiation, and burning pain.
Via their distinctive axonal terminals, called cartridges, these cells selectively target the axon initial segment of pyramidal cells and control action potential initiation; however, the mechanisms that govern the characteristic ChC axonal structure have remained elusive.
Naundorf, B., Wolf, F. & Volgushev, M. Unique features of action potential initiation in cortical neurons.
Koch, C., Bernander, O. & Douglas, R.J. Do neurons have a voltage or a current threshold for action potential initiation?
Hu, W. et al. Distinct contributions of Na v 1.6 and Na v 1.2 in action potential initiation and backpropagation.
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"The spatial and temporal patterns of action potential initiations were studied in a behaving leech preparation to determine the basis of increased firing that accompanies sensitization, a form of non-associative learning requiring the S-interneurons.
The functional consequence of differences in anatomical architecture was tested by constructing network models representing sequential steps of mechanosensory encoding: skin displacement at touch receptors, mechanotransduction and action-potential initiation.
Since action potentials initiate at the AIS, being able to control neuronal depolarisation (or hyperpolarisation) specifically at that initiation site should allow precise temporal control over firing behaviour.
We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons.
Published: October 29, 2015 The axon initial segment (AIS) is a molecularly defined specialization of the proximal axon that, because of its morphology, cable properties, and high density of voltage-gated sodium channels, is the site for action potential (AP) initiation (Bender and Trussell, 2012, Clark et al., 2009, Kole and Stuart, 2012).
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