Sentence examples similar to action on targets from inspiring English sources

The analysis of overrepresented combinations of disease classes and molecular mechanisms of drugs shows that the phenotypic impact of certain drug classes is linked either to their therapeutic action (on-targets) or to closely related off-targets.

Insulin mediates its action on target organs through phosphorylation of a transmembrane-spanning tyrosine kinase receptor, the insulin receptor (IR).

Diabetes mellitus is a metabolic disorder characterized by abnormal carbohydrate, protein and fat metabolism due to deficient insulin action on target tissues which results in hyperglycemia [1].

The sympathetic nervous system, through β-adrenergic receptor (βAR) action on target tissues, is likely the efferent arm of this homeostatic mechanism.

Sometimes there might be hidden or unknown drug targets that are not considered in this study resulting in a bias since drugs trigger their action on target genes and have a consequent effect on other off-target genes.

The consequences of T cells' action on target astrocytes is explored by our work.

However, the downstream implications of such short-term fluctuations in serum concentration for glucocorticoid action on target tissue have not been explored.

Taken together, the data form a coherent hypothesis that cdr2 action on c-myc leads to a concerted action on target genes to promote cellular proliferation, and that this action is inhibited by cdr2 knockdown.

We construct our model supposing an action on target translation.

The understanding of miRNA biogenesis and action on target mRNAs is significantly advanced.

Aglepristone is known to block the progesterone action on target cell receptors.