Sentence examples for action of trail from inspiring English sources
As HDACIs strongly enhance the apoptotic action of TRAIL even at low concentrations, HDACIs may be used in combination with TRAIL to reduce the doses of TRAIL required for inhibition of tumour growth.
To this end, we selected thapsigargin (TG), an agent known to cause perturbations in intracellular Ca2+ homeostasis to enhance the apoptotic action of TRAIL.
Accordingly, an improvement of the tumor-selective action of TRAIL appears mandatory.
The basis for the tumor-specific action of TRAIL is that during malignant transformation cells become sensitive to TRAIL [ 1].
Indeed, it has been shown that RA induces apoptosis of APL cells and APL patient blasts through selective paracrine action of TRAIL.
To analyse the detailed mechanisms by which these HDACIs enhance the action of TRAIL, the cell surface expression of TRAIL and the TRAIL-receptors was measured by FACS.
Given the literature reports of other potential mechanisms of action for TRAIL sensitizers, characterization of the TRAIL-sensitizing activity of withanolide E included assessment of effects on apoptotic protein expression, proteasomal activity, generation of ROS, ER and mitochondrial stress, and death receptor expression.
It seems in this case that the lift of the bCOM is not a consequence of a pulling action of the trailing arm, but it may be an inertia effect, because the vertical bCOM velocity is still relatively high at the beginning of double hand contact.
The available evidence on the mechanisms of action, in vivo, of TRAIL and inhibitors as AZD6244 led us to hypothesize that their association might have anti-tumor effects not only uniquely exerted through induction of apoptosis but also through inhibition of angiogenesis.
To more closely mimic the action of the trimeric TRAIL ligand on the receptors, the agonistic antibodies were crosslinked with a secondary antibody through their Fc regions.
At first sight, therefore, TRAIL- β and TRAIL- γ may interfere with the fine tuning of TRAIL actions simply by reducing the amount of full-length ligand.
