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This indicates the action of deacetylation.
An increase in activity and decrease in stability has also been seen as a consequence of deacetylation on the FoxO family [ 59], consistent with a possible coordinated action of deacetylation and methylation.
Similar(58)
The observation that genes with trithorax binding sites are among those selectively activated by the MOF/NSL complex further suggests that a trx-MOF-Sir2-PcG pathway may be broadly used in development (Feller et al., 2012) such that the sequential actions of H4K16 deacetylation then PcG repression terminate transient developmental gene expression.
(1) The PcG complex that contains EED and enhancer of zeste homolog (EZH) proteins 1 and 2 recruits HDACs and represses transcription of target genes by the combinatory action of local histone methylation and deacetylation.
SIRT1 was also shown to improve insulin sensitivity by repressing transcription of protein tyrosine phosphatase 1B, a major negative regulator of insulin action, via histone deacetylation [ 15].
Degree of deacetylation.
The degree of deacetylation was 85%.
The treated chitin was further subjected to enzymatic deacetylation employing chitin deacetylase from P. oxalicum SAEM-51 to produce chitosan with considerably higher degree of deacetylation.
Chitosan (MW = 1 × 105, degree of deacetylation = 98%) was purchased from Fluka (Buchs, Switzerland).
The degree of deacetylation was determined as 87 mol% by colloidal titration.
The use of chitosan in diverse areas is directly related to the polymer's molecular weight and degree of deacetylation, which depends on the conditions of chitin deacetylation.
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