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Thus, it is necessary to clarify the mechanisms of action of candidate miRNA overexpressed in neonates on the levels of haemostatic proteins.
To facilitate drug discovery and development, methods are needed to identify cellular targets and elucidate the mechanisms of action of candidate chemical compounds.
This is the first animal model in which the action of candidate anti-HIV-1 compounds can be tested within the setting of an intact HIV-1-infected human target organ.
Furthermore, adverse side effects can be expected from systemic administration and/or broad-spectrum action of candidate agents.
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The actions of candidates who ran and our respective political party national committees are in the past.
The application of BIOTA could allow to hypothesize the mechanism of action of a candidate drug prior to its biological evaluation or to repurpose old drugs.
This modular instrument can be used with appropriate individual modules customized to the mechanism of action of a candidate therapy, from purely anti-inflammatory medications, to those targeting pain, dysmotility, or functional symptoms.
Although numerous studies have focused on the mechanisms of action of the candidate chemotherapeutic drug MIRA-1/NSC19630, initially described as a mutant p53-reactivating small molecule, the issue of its toxicological evaluation remains open.
Our high-content image-profiling method also allows direct and systematic identification of drug targets from 4718 nonessential genes without any prior knowledge of about the mechanism of action of the candidate drug.
Understanding the mechanism of action of a candidate therapeutic antibody against solid tumors requires a detailed physicochemical understanding of specificity and immune effector functions as well as the in vivo pharmacokinetics and biological activity in normal and tumor sites.
To determine whether the synergistic action of the candidate molecules represents a general mechanism for the induction of DA neurons from hESC, we extended our analyses to two other hESC lines, BG02 and BG03, with normal karyotypes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com