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With an onset of action of approximately 10 min and unparalleled relief of migraine headache and associated symptoms [14], SC sumatriptan has been the most effective acute migraine therapy since its introduction nearly 25 years ago [2].
These changes produce an insulin with a duration of action of approximately 24 h or more after subcutaneous injection, without pronounced peaks of activity [ 10].
Thus, the available evidence shows that topiramate has an onset of action of approximately 1 month, similar to that of propranolol.
A significant decrease in blood pressure is usually observed 5 10 min after nifedipine administration, with a peak effect at between 30 and 60 min and a duration of action of approximately 6 8 hours [ 129].
The PDE4 family acts to regulate downstream signalling events induced by cAMP, and does so via the action of approximately 25 different isoforms that arise as multiple splice variants encoded by four distinct genes (PDE4A, B, C and D) [8].
The insulins lispro and aspart achieve peak concentration within 90 minutes and have a duration of action of approximately three to five hours (Bode 2004), while glulisine's peak concentration is within an hour, and its duration of action is roughly two hours (Drug Guide 2005).
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"Gavin has had his injection and will now be out of action for approximately a month.
She defended the title until she suffered a legitimate broken hand in July that caused her to be out of action for approximately a month.
DiBiase and Rhodes attacked each other during the match, ending the duo, and Rhodes was punted by Orton and taken out of action for approximately a month.
After a strong start to the following season for both club and player, Jarvis injured his hamstring in the defeat to Reading on 30 September 2008 and was expected to be out of action for approximately six weeks.
Its extended duration of action (half-life of approximately 5 days) allows for once-weekly dosing [ 6– 8].
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