The phrase "action nucleotide" is not a standard expression in written English, but it could be understood in a specific scientific context.
You can use it when discussing molecular biology or biochemistry, particularly in relation to nucleotides that play a role in cellular processes.
Example: "The action nucleotide involved in the signaling pathway is crucial for the cell's response to external stimuli."
Alternatives: "functional nucleotide" or "active nucleotide".
Platelet phosphodiesterases (PDEs) counterbalance the action of nucleotide cyclases [ 2- 5].
Thus, CTC-96 has a completely different mode of action than nucleotide analogs as well as other DNA replication inhibitors.
Therefore, the likely combined action of nucleotide-sensing TLR3, TLR7, and TLR9 in host defense against T. gondii was suggested [ 21].
The inactive Rac-GDP is then exchanged for GTP through the action of guanine nucleotide exchange factors (GEFs), Tiam1 and Trio, which are located on the membrane.
Although drugs such as hydroxyurea can be used to effectively synchronize cells at the level of DNA synthesis [20], [43], [44], the mechanism of action (deprivation of nucleotide precursors via DHFR-TS inhibition) is somewhat similar to the general nutrient deprivation technique we had already employed, and might similarly cause changes in starvation- or stress- regulated transcripts.
In the current model (described in yeast but applicable to mammals), the GDP-bound form of Scarl-1p (HsARL-1) is cytoplasmic; when GDP is exchanged with GTP under the action of the nucleotide exchange factor, Scarl-1p (HsARL-1) moves to the Golgi membranes and recruits GRIP domain proteins [30] [62], [62].
Here the ICL is 'unhooked' from one strand via the action of the nucleotide excision repair-associated endonuclease ERCC1 XPF protein complex.
The mutation in the P-loop of the G domain could either stabilize the catalytic conformation and prevent exchange of ADP to ATP (Li and Zhang, 2004), or impair the action of potential nucleotide exchange factors facilitating ADP to ATP exchange.
ICLs can be repaired in G0/G1 cells by the combined action of the nucleotide excision repair machinery that unhooks and excises the crosslink and translesion DNA polymerases that ensure DNA repair synthesis (Ben-Yehoyada et al. 2009; Sarkar et al. 2006; Shen et al. 2009).
It is ascribed to its agonist action on the nucleotide-binding oligomerization domain-containing protein 2 (NOD2).
