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Progesterone counterbalances oestrogen and diminishes oestrogenic action in the endometrium.
This idea is supported by the reports that estrogen stimulates the expression of IGF-1, and IGF-1 is required to mediate estrogen action in the endometrium [ 13, 14, 22].
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As these studies were performed using whole-uterine tissues, it is possible that this represents a paracrine action involving the endometrium, stroma and myometrium.
It can induce experimental tumours by both hormonal and DNA-damaging mechanisms, but its carcinogenic mode of action in human endometrium remains unclear.
Apart from E2-mediated acute improvement of islet-graft oxygenation, the likely action of oestrogens involves the enhancement of islet revascularisation through action on recipient endothelial cells, as E2 is a potent angiogenic factor in the endometrium and following vascular injury [ 22, 23].
Our results suggest that PROK1-PROKR1 has a role in the modulation of angiogenic events in the endometrium in part via IL-8, and that this process could be modulated by the action of RCAN1-4.
Likewise, it was shown that E2 regulation of ERα immunostaining showed a similar pattern in epithelial and stromal cells in the endometrium of prepubertal lambs, but there were cell type specific differences in timing and strength of E2 action [ 19].
Soon the entire blastocyst is buried in the endometrium.
Hysterosonography may be of further help in identifying an irregular, inhomogeneous mass or focal thickening in the endometrium [54].
To examine the expression of syndecan-1 in the endometrium during the menstrual cycle.
To evaluate the expression of L-selectin ligand in the endometrium during the menstrual cycle.
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