Sentence examples for acting regulation from inspiring English sources
All of 11 eQTL, which were detected in this region, showed trans acting regulation of expression.
By these definitions of cis and trans acting regulation out of 104 eQTL that coincided with pQTL for drip, 96 belong to genes that had trans acting regulation of transcription, 8 genes had cis acting transcriptional regulation (Table 6).
In particular functional positional candidate genes under cis acting regulation are of high priority for further analysis.
Using this approach we identified at least >1000 genes that are under cis acting regulation in adipose tissue of adult mice, including genes implicated to be involved in adipogenesis and other processes relevant to common human diseases.
A linkage analysis of abundance of trait correlated transcripts revealed 897 expression QTL (eQTL) with 104 eQTL coinciding with QTL regions for water holding capacity; 96 transcripts had trans acting and 8 had cis acting regulation.
Cis- acting regulations represent polymorphisms in physical linkage to the gene, affecting the transcription in an allele-specific manner.
Consequently, cis-eQTLs are usually detected as local-eQTLs, being mapped in the vicinity of the gene; whereas trans-acting regulations act distantly in a non allele-specific way and can be located anywhere in the genome, most likely detected as distant-eQTL [ 1, 11, 17].
This suggests that these proteins may be involved in DNA binding, probably acting in regulation of gene expression.
The TP53 pathway is crucial for tumour suppression, acting through regulation of cell-cycle control, apoptosis, senescence and DNA repair.
Several reports demonstrate that Tau plays pivotal roles in central nervous system homeostasis, acting on regulation of osmotic pressure, antioxidation, neuromodulatory processes, and inhibitory neurotransmission.
This excludes all riboswitches found to be mutually conserved in all compared chromosomes, strengthening a hypothesis implicating cis acting RNA regulation as an ancient mechanism [ 36].
