Sentence examples for acting on target from inspiring English sources

In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, dFOXO is activated and inhibits growth through acting on target genes such as Thor (d4E-BP) [ 31].

According to the latter, l-DOPA produced in monoenzymatic TH neurons is secreted and plays a role as neurotransmitter or neuromodulator acting on target neurons via catecholamine receptors, such as dopamine D2 (reviewed by Ugrumov 2009).

Since Vps15-depleted cells have decreased levels of PI3P, it is tempting to speculate that PI3P are indispensable for autophagosome maturation by acting on target proteins such as TECPR1.

We determined which of the 140 screen-reproducible siRNA pools were likely acting on target initially by quantitative RT-PCR (qRT-PCR) to determine which siRNA pools resulted in significant target transcript knockdown 48 hours after transfection into 184- hTERT-L9 cells.

The effect of adipose tissue reduction on lifespan could be due to the production of adipokines acting on target tissues such as the brain, or due to the indirect prevention of age-related metabolic disorders like type 2 diabetes or atherosclerosis [ 31].

15, 20 In addition, there was a corresponding increase in the TbTryS substrate GSH, providing strong evidence that these compounds were acting on-target.

Hence the preponderance of evidence presented in this study indicates that these molecules are acting on-target and are therefore reliable tools for probing MCL-1 function in vitro.

26 As this large potency shift between the enzyme IC50 values and parasite EC50 values was unexpected, further experiments were carried out to confirm whether hit compounds were entering the cell and acting on-target.

14 Given that bumetanide is likely to inhibit NKCC1 from an extracellular site by binding within the translocation cavity in the third transmembrane helix, 80 its high ionization is not a problem for use in vitro, or for acting on targets in vivo that are not protected by the BBB (e.g., NKCC1 expressed on the luminal membrane of the cerebral vascular endothelium).

More recently, the use of RNAi, a supposedly more specific tool acting on one target protein, permits a less complex interpretation of phenotypes.

From (7) to (10), one can get the following conclusion: The squeeze force of a sliding tube acting on the target object is F_{text{s}} = frac{{2ieta l_{text{OA}} T_{ 0} }}{{3l_{text{OB}} d_{ 2} }} - frac{{M_{text{o}} }}{cos theta }. (12).