Thus, VRK2A is acting at two different levels in the modulation of the cell response to induction of apoptosis: protein protein interaction and transcriptional regulation.
Vitamin A is an essential micronutrient that regulates many biological processes through modulation of retinoic acid receptor-responsive genes, acting as a systemic antioxidant and participating in the modulation of diverse redox mechanisms involved in physiological and pathological processes.
On the basis of these findings, we suggest that miR-145 may have a role in the modulation of CRC metastases, acting as a metastamir, by targeting Fascin-1.
Moreover, dopamine cells located in the vicinity of the photoreceptors modulate the light-off induced swimming behavior of ascidian larvae by acting on alpha2-like receptors, instead of dopamine receptors, supporting a role in the modulation of the photic response.
Adrenomedullin has been implicated in the modulation of various physiological functions, ranging from vasorelaxation to acting as a regulator of cell growth (Hinson et al, 2000; Nikitenko et al, 2002).
Overall our data show that Rlf has a prominent role in the modulation of epigenetic state at cis-acting regulatory regions across the genome.
Regarding endocannabinoid involvement in the modulation of the NTS neural activities, it has been shown that, by acting on presynaptic cannabinoid CB1 receptors, they inhibit both excitatory and inhibitory signalling in the NTS [ 47].
mRNA secondary structures can play roles in the modulation of splicing, for example, by hiding or revealing splice sites and other regulatory elements or by modifying the spatial distance between cis-acting elements.
Overall, these data suggest that the selective pressure acting on albumin is related to the modulation of its extraordinary ligand-binding adaptability in response to variable environment conditions, possibly including adaptation to hibernation/torpor.
