EZH2 works together with other components such as embryonic ectoderm development and suppressor of zeste 12 to form the polycomb repressive complex 2, which interacted with target gene promoters, thereby acting as a transcriptional repressor via chromatin modification.
> -wrap-foot> Previous work indicates a potential gene regulatory role of PML bodies (Block et al., 2006; Lallemand-Breitenbach and de Thé, 2010), beyond that of acting as a site for post-translational modifications (Song et al., 2008; Gupta et al., 2008).
If the latter is true, our observations would indicate that only the modified form of LYL1 is subjected to degradation with the modification itself acting as a signaling event.
CYLD, a NF-κB inhibitor acting as a tumour suppressor, is phosphorylated by IKKε, a modification that decreases its deubiquitine ligase activity and consequently its inhibitory potential [ 21].
Cytosine methylation is a key epigenetic modification in vertebrates, acting as a focal point for mechanisms that suppress gene expression.
Mammalian methyl-CpG-binding protein-2 (MeCP2) recognizes methylated DNA and associates with SIN3A and HDAC1 histone-modifying enzymes, acting as a bridging factor between DNA methylation and histone modifications [ 67].
Antennas generate a modification on the wind flow around the tower acting as a screen against wind load and transmitting strong efforts to the tower members.
"Climate change is acting as a brake.
The current interest in developing devices for solar powered energy conversion and storage, as well as light-induced catalytic removal of pollutants has recently prompted attention to the modification of TiO2 nanotubes with Cu2O, acting as a visible light sensitizer.
The process of chemical modification proceeded in several stages, analogous to the process of chemical modification, to obtain a suitable surface compound acting as a source of benzene.
These data suggest that DMRs, acting as a driver of the specific gene expression, not only globally regulate gene expression via modification of cis-acting DNA elements [ 21, 22, 27] but also govern gene transcription through effects on the expression of trans-acting factors.
