These data suggest that Src kinases and RhoA/ROCK might act in the same signalling pathway.
Moreover, ABI4 (an AP2 family protein) and various basic-leucine zipper (bZIP) TFs including ABI5 or EEL (ENHANCED EM [EMBRYO MORPHORGENESIS] LEVEL) are known regulators of the expression of SEED STORAGE PROTEIN (SSP) genes, which act in the same signalling network but downstream of ABI3 [ 28, 29].
PI3K and SFKs can act in the same signaling pathway or in independent pathways to transduce signals to downstream effectors leading to the activation of actin cytoskeleton.
To determine whether the same key regulation factors act in the same signaling pathways in both pig and mouse embryos during PED, we analyzed signaling pathway patterns relevant to development or pluripotency: the TGF-beta, MAPK, Jak-Stat and Wnt pathway.
This indicates that TOR and autophagy act via the same signaling pathways to affect lifespan.
This view is corroborated by the fact that the long stalks of the agb1-1 mutant were very poorly colonized, thus behaving very differently from the erecta mutants, despite the fact that both AGB1 and ERECTA act in the same signalling pathway.
How would they have acted in the same situations?
In addition, multiple miRNAs can act on the same signaling pathway or biological process [ 14- 17].
Although a role for activin B in cachexia is yet to be established, activin B can act through the same signaling pathway via Smad 2/3/4 and also can activate the pathway via ALK7, another type 1 receptor [ 50].
Subsequent studies showed that Age-1 and Daf-2, as well as Daf-16 and Daf-18 (mutations in which suppress life span extensions caused by Daf-2 and Age-1 mutations) act in the same signal transduction pathway [ 11].
The non-complementation between the swd/+ and trpm7 j124e1/+ heterozygotes argues against the possibilities that the swd- and trpm7-encoded proteins are different effectors that act in the same signaling pathway, or that the swd and trpm7 loci are different genes that are closely located near each other.
