The phrase "acted as a significant" is correct and usable in written English.
It can be used when describing a role or function that has considerable importance or impact in a particular context.
Example: "The new policy acted as a significant catalyst for change within the organization."
Alternatives: "served as a major" or "functioned as an important".
In Soviet times overseas support for "dissidents" acted as a significant restraint on the authorities.
An OECD study published in 2011 found that high legal fees on home purchases acted as a significant disincentive to moving.
The sell-off accelerated late in the trading session after the Standard & Poor's 500-stock index fell below the 1,500 level, which has acted as a significant support point.
This has made its exports more expensive and, in the view of Prime Minister Abe, acted as a significant brake on growth.
This report was widely publicized at the time but has acted as a significant catalyst, with Belgium taking action to reverse the trend and instead the country has now established itself as one of the continent's safest jurisdictions in which to invest.
Indeed, the strength of the genetic interaction acted as a significant predictor of the number of common interactors the corresponding signaling genes exhibit (Fig. 3, those pairwise interactions with the strongest IS –and thus with the largest number of common target interactors– involved query genes which were orthologs of members of the fibroblast growth factor pathway).
Results show that housing deprivation acts as a significant exploratory factor for all the health outcomes.
To the extent that the rump Placing is as large as we contemplate, this could act as a significant technical overhang to the stock".
The book's findings indicate that the geographic dispersion of MNC production acts as a significant force for peace among the great powers.
The barriers to entrepreneurship in Germany are often obscure, but cumulatively act as a significant drag on job creation and investment.
In short, limestone is not likely to act as a significant in situ capture method for HCl in a fluidized bed.
