This protein binds mono- and di-methylated H4K20 and contains three MBT domains which act in concert to interact with methylated H4K20 (isolated MBT domains do not bind peptides, unlike bromodomains).
Furthermore, these data demonstrate that molecules such as oxidants, antiproteinases, and chemokines, rather than act independently, are likely to interact to cause emphysema.
Several lines of evidence show that TACC family members comprise adaptor proteins, by which these members act as a hub to interact with multiple effector molecules [11 14].
Collectively, these studies indicate that TACC proteins may well act as a hub to interact with multiple proteins to play distinct roles in different stages during mitosis (Fig. 2B).
At the same time, Phe351 acts as a 'fastener' to interact with Aux/IAA and prevent the substrate from leaving.
An E3 ligase acts as an adapter to interact with both E2 and substrates and promote the transfer of SUMO from E2 to specific substrates [23].
Importantly, our simulations are of physical cells in a physically realistic environment, in which cells act as individual agents able to interact only with their local environment.
These five TFs have been shown to interact and act at diverse stages of the hematopoietic program; i.e., from the onset of its development to the more established adult hematopoietic hierarchy (Wilson et al., 2010).
These are now known to interact and act cooperatively or competitively during difference stages and conditions of learning (Foerde et al., 2006; Moody et al., 2004; Poldrack et al., 1999, 2001b; Seger and Cincotta, 2006; Wang et al., 2010).
Given the direct interaction between Cox-2 and Runx2, we speculate that Cox-2 may act as a co-factor to interact with Runx2, which has DNA-binding capability, together to achieve their control over Col10a1 expression and chondrocyte hypertrophy.
