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It is an environment that was foreshadowed by Felsenstein ("gene substitutions act to counteract the effects of environmental change, as if the population were running as hard as it could to stay in the same place". [ 9]).
These data suggest that elevation of NOX4 could act to counteract the hypertensive effects of angiotensin II and thereby act in opposition to the pro-hypertensive effects of NOX1 and NOX2 (Fig. 2).
The rapid evolution of IFITMs could be linked to their capacity to act as anti-viral agents; frequent mutation and duplications of these genes may act to counteract virus adaptations [ 12].
Whereas an insufficient increase in capillary number relative to increase in cardiomyocyte size during hypertrophy is thought to promote pathological remodelling of the heart [ 104], the NOX4-dependent preservation of capillary density may act to counteract this (Fig. 3).
Instead, they act to counteract outgrowth, and importantly this leads to the development of a looped tubular structure both by tethering the distal tips of tubules close to their proximal junction with the ureter and by maintaining the tightness of the tubule kink region.
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Third, synaptic inhibition of Purkinje cells, whose complex spike-elicited plasticity acts to counteract PF-PC conjunctive LTD, seems to play a role in motor learning [22], which is ignored by models that rely exclusively on PF-PC LTD.
Constructive interference produced by the superposition of sensory signals with well-matching forward predictions acts to counteract surround suppression.
Retinal melatonin appears to play a paracrine role in dark-adaptation processes [ 34] and retinal AANAT further acts to counteract light-induced retinal degeneration [ 47].
The yoga component of the course may also have acted to counteract the cycle of inactivity or agitation frequently encountered in depression.
It is likely that treatment of hyperglycemia with insulin acts to counteract inflammatory response and poorer outcomes in critically ill patients by a dual mechanism of a direct anti-inflammatory effect of insulin as well as lowering the proinflammatory effects of glucose.
Amandine Everard and coauthors tested the impact of prebiotic treatment on mice that were fed high-fat diets and found that the differing composition in microbiota of treated mice acted to counteract inflammation and metabolic disorders induced by the high-fat diet (Everard et al. 2014).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com