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Hormones act on their target tissues by binding to and activating specific molecules called receptors.
There are two postulated methods by which miRNAs act on their target genes.
After secretion, vesicles can act on their target cells through several mechanisms.
Catecholamines act on their target cells through binding to cell-surface adrenergic receptors.
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Therefore, it has been thought that chromatin-remodeling enzymes can utilize the bromodomain to find and/or act on their targets.
The miRNA are subsequently incorporated in the miRNA-induced silencing complex (miRISC) so that they can act on their targets.
Immune modulating proteins need to be secreted in order to act on their targets outside the bacterial cell.
However, under certain stressful circumstances such as nutritional stress, colonization of new hosts, DNA-damaging agents, etc., transcription of the TA will be triggered, and the labile antitoxin will be degraded more rapidly, unleashing the toxin protein to act on their targets.
Glucagon and secretin are two relevant hormones that act similarly on their target cells (hepatocytes and cholangiocytes, respectively).
Eg5 inhibitors tested in the clinic act reversibly on their target, and thus mitotic arrest must be maintained long enough to elicit cell death.
By using different methods and experimental conditions, Leverson et al. also demonstrated that A-1210477 and its related analogs penetrate living cells and act directly on their target MCL-1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com