Sentence examples for act on targets from inspiring English sources

Small-molecule drugs (defined by their low molecular weight, typically less than 500 daltons) act on targets that are inside the cell.

The majority of the targeted therapies are either small-molecule drugs that act on targets inside the cell (usually protein tyrosine kinases) or monoclonal antibodies directed against tumour-specific proteins on the cell surface [ 54].

Discussion: Our results indicate that assessment of the inhibitory effects of agents on spontaneous [Ca2+]i oscillations in neurons may be useful for the identification of agents that act on targets for which specific screening methods are not currently available, or those which act via a previously unknown pathway to inhibit synaptic transmission.

First, the ribonucleoprotein complexes act on targets immediately after injection.

TKI, being small, are indeed able to pass through cell membranes and can act on targets in the cytoplasm regardless of their cellular location, yet once in the cell they do only one thing: inhibit kinase activity.

The lead compounds do, however, show a robust biochemical effect in T. brucei, and are proven to act on-target, inhibiting TbTryS in cells.

These findings indicate that such a combination treatment acts "on target".

These act on target sites through two receptors, HCRT receptor-1 and HCRT receptor-2.

Glucocorticoids are steroid hormones that act on target cells through interaction with a specific glucocorticoid receptor (GR) [ 2].

The cytokines act on target cells by binding to specific cytokine receptor ligands, initiating signal transduction and second messenger pathways within the target cell [ 14].

Transcription factors act on target genes in concert and as more becomes known about TBX1 protein interactions the effect of this mutation on protein interactions should be investigated.