The phrase "act on expression" is not commonly used in written English and may be unclear in meaning.
It could be used in contexts where one is discussing responding to or taking action based on a particular expression or statement.
Example: "In order to improve team dynamics, we must act on expression and address any concerns raised by team members."
Alternatives: "respond to expression" or "react to expression".
However, arsenic may also act through other mechanisms; one plausible is that arsenic acts on expression of telomere binding proteins that stabilize the telomere structure.
Given this lack of activating/recruiting capacity, it is to be expected that GlnR will only act on the expression of one gene in various divergons, like for instance on tnrA but not ykzB[ 58] and on pucH but not pucR[ 59].
This first genome-wide exploration of interaction between cis eSNPs and risk factors on gene expression therefore suggests that the two sources of variability mostly act additively on expression.
Yet, we also found that tenovin-1 diminished BCL2 expression in p53+ and p53− cells, showing that tenovin-1 can act on gene expression in a p53-independent manner, though its cell-killing action had the requirement for p53.
Although there is strong evidence of the modulatory effects of n-3 PUFA on gene expression in several cell types in humans, it is not known if they could act on gene expression by altering the epigenetic mechanism of DNA methylation.
It was recently suggested that regulators other than PlcR could act on the expression of PlcR-controlled genes [43], [44].
Anti-inflammatory interleukins such as IL-4 and IL-10 are inducers of arginase isoforms, although these cytokines are known to act on the expression of arginase I, but not that of arginase II [28].
Antisense RNAs act on gene expression by a variety of different mechanisms.
The identification of certain compounds that would have the ability to act on the expression of target genes is extremely important in preventing diseases such as cancer.
One should also consider that perhaps it is not weight at one timepoint around breast cancer diagnosis, but rather weight trajectories over the life course that may act on gene expression or tumor subtype [ 47].
