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Given that both PACAP38 and CGRP act on cell membrane receptors one would expect a similar median time to migraine onset after infusion.
When cells are exposed to hormones that act on cell surface receptors, information is processed through the plasma membrane into the cell interior via second messengers generated in the inner leaflet of the plasma membrane.
Sunitinib and pazopanib act on cell surface receptors known to be aberrantly activated in cancers.
The cAMP pathway may act on cell cycle, by activating PKA that translocates between subcellular compartments.
Vasopressin, norepinephrine, and angiotensin II act on cell surface receptors that couple with G-proteins to effect vasoconstriction.
However, polyamines do not act on cell growth only via hypusination, and also regulate translation initiation via eIF2α and 4E-BP.
Similar(38)
Commonly, these agents act on cells that divide rapidly, one of the main properties of cancer cells.
The putative inhibitor, which we tentatively call ILMR (inhibitor of LPA-mediated responsiveness) seemed to act on cells (instead of at the level of LPA) by suppressing the ability of LPA receptor 1 to signal.
Mechanical signals act on cells in a magnitude dependent manner to induce bone deposition or resorption.
Although different TGF-β members have distinct cellular functions, they all act on cells as dimers.
Therefore, these two effects may act on cells independently.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com