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The only practical difference between them is that they act at different ends of the molecules that form the switches.
In order to accomplish this, it will be important to understand the similarities and differences between novel mGlu5 PAMs that act at different allosteric sites.
Each of these agents can act at different time-scales (i.e., act asynchronously).
There is an increasing number of clinical trials testing new compounds which act at different stages of Multiple Sclerosis (MS).
The advantage of the method is that provides alternative control structures able to act at different operating points.
The improvement is attributed to the combined effects of two different reinforcements that act at different scales.
These act at different points in the biochemical pathway that causes eyes to produce too much fluid.
In light of this, drug combinations that can act at different levels of the neurotoxic cascade offer new avenues toward curing Alzheimer's and other neurodegenerative diseases.
Our results indicate that Plk1 and separase act at different times during M phase to license centrosome duplication, reminiscent of their roles in removing cohesin from chromosomes.
Chun, J., Buechelmaier, E. S. & Powell, S. N. Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
Therefore, protease inhibitors are generally used in combination with other antiretroviral agents, especially agents that act at different points in the life cycle of HIV.
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CEO of Professional Science Editing for Scientists @ prosciediting.com