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Simulated study scenarios provided insight into the relative contributions of different types of costs, and can act as a sensitivity analysis of the components in the overall cost model.
While the investigators anticipate that the intention-to-treat and per-protocol analyses will return the same pattern of findings (not many participants are likely to have an acute length of stay of greater than 14-days), the per-protocol analysis will act as a sensitivity analysis with pragmatic implications for the subsequent potential translation of the intervention into health services.
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Microscopy counts of cell viability after treatment with H2O2, C2-ceramide, or staurosporine (STS) revealed that miR-25-expressing HeLa cells were strongly protected from death caused by C2-ceramide and H2O2, apoptotic challenges for which mitochondrial Ca2+ loading acts as a sensitizing factor [ 16 18], whereas the sensitivity to STS was unaffected.
Meanwhile, miR-320 is able to inhibit HL-60 cell proliferation by suppressing receptor 1 (TfR-1; CD71) [ 72], and miR-181a was believed to act as an intrinsic antigen sensitivity "rheostat" during T cell development [ 73].
Therefore, local baseline Fkbp5 mRNA levels can act as a marker of GR sensitivity in that specific brain region.
It was also not expected from earlier experiments suggesting that Ly49 receptor downmodulation would act as a mechanism to increase sensitivity to very small changes in MHC class I levels [41].
To address the possibility that death may act as a competing risk, we conducted sensitivity analysis where death was considered as a competing risk instead of being a censoring variable (Andersen, 1993).
As minisatellites do not appear to be the direct target of mutagen-induced DNA damage (Dubrova et al, 1996, 1997), it is thought that they may act as a marker for general genome sensitivity or instability (Niwa, 2003).
Hartge et al. [ 18] previously showed a gradient of decreasing NHL risk with increasingly light eye color, one pigmentation phenotype believed to act as a marker of increased sun sensitivity.
The VP1 region showed 2 reversions of the capsid determinant; C2493→U appear to be the main determinants of the attenuated phenotype (1 ), and at position 54 for alanine amino acid mutated to valine (Ala54→Val) that can act as a suppressor of the temperature sensitivity and attenuated phenotype (13 ).
Work by Wilson and Nicholl found that the cannabinoids themselves act as a feedback mechanism that regulates the sensitivity of nerve cells that prevents excessive activity.
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