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In G. mellonella, apoLp-III interacts with several immune elicitors such as lipopolysaccharide [16], lipoteichoic acid [14], and beta-1,3-glucan [17], suggesting that apoLp-III may act as a pattern recognition or as a carrier molecule.
Interestingly, an increase in prion protein expression has been demonstrated during bacterial infection[20] and inflammation[18], and hence it has been hypothesized that PrPc may act as a pattern recognition receptor inducing the innate and adaptive immunity in a TLR independent manner[25].
The fact that the peptide backbone of the MG-H1-containing proteins is not involved in RAGE binding indicates that RAGE may act as a pattern recognition receptor.
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The transferred PDMS skin preserves the original hydrophobic nature of PDMS (static contact angle ~113°) [27] and thus can act as a patterned resist for selective wetting and deposition of SWCNTs.
Each particular sequence of three nucleotides in the nuclear DNA acts as a pattern for the production of exactly the same amino acid in all organisms.
By both protein-microbe interaction analysis and enzyme-linked immunosorbent assay as well as phagocytosis test, we demonstrate for the first time that fish Vg acts as a pattern recognition molecule with multiple specificities that can recognize bacteria as well as fungus rather than self components from fish, and functions as an opsonin that can enhance macrophage phagocytosis.
TLR2 acts as a pattern recognition receptor and signals the presence of various bacteria through the activation of NF-κB, not only in human and mouse, but also in chicken [ 32- 35].
We show that DNA-PK acts as a pattern recognition receptor, binding cytoplasmic DNA and triggering the transcription of type I interferon (IFN), cytokine and chemokine genes in a manner dependent on IFN regulatory factor 3 (IRF-3), TANK-binding kinase 1 (TBK1) and stimulator of interferon genes (STING).
Studying downstream signaling cascades and transcription regulation Jeremy Luban suggested that TRIM5 acts as a pattern-recognition receptor to detect HIV and trigger an intracellular antiviral response.
It is demonstrated for the first time that Vg from fish Hexagrammos otakii (Jordan & Starks) can not only act as a multivalent pattern recognition receptor binding to LPS, LTA, peptidoglycan (PGN), glucan and laminarin, but also function as an opsonin promoting macrophage phagocytosis.
NOD2 was shown to act as an intracellular pattern recognizing receptor for ssRNA viruses.
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