Ang-2 has been shown to act as a context-dependent antagonist or agonist for Tie-2 with the antagonism as the best described effect [9], [10].
What potential mechanisms could then lead to cell type-specific and ligand-specific signaling differences for GDF-5 and enable GDF-5 to act as a context-dependent antagonist against BMP-2?
Houk and Wise (1995) described a localistic firing-rate model of the interaction between thalamo-cortical loops and the basal ganglia in which the striatum acts as a context detector, linking motor behaviours to the right contextual patterns.
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene.
Another example of a neuronal subtype-specific transcription factor is Runx1 (Runt-related transcription factor 1). Like the two other members of the mammalian Runt-related protein family, Runx1 acts as a context-dependent transcriptional activator or repressor [5], [6].
In contrast, JunB acts as a context-dependent tumor suppressor (Passegue et al., 2001).
Therefore, it is possible that TLK2 acts as a context-dependent driver of ER-positive/luminal tumours in the absence of PIK3CA expression.
Using Normalization Process Theory [ 19] as an analytic framework, Hoshin Kanri might act as a component of context that enables, constrains, resources and realizes people and procedures with the goal of changing people's actions.
Acting as a constant context monitoring agent, a tablet or a smartphone can expand the capacity of a shoop floor system actor to carry out asset management tasks.
Our report highlights that one such factor is the increased sexualisation of women and girls in the media and popular culture – the "pornification of culture" – which acts as a conducive context for violence against women by normalising the portrayal of women and girls as sex objects, not people.
Our work contributes to the understanding of why trust establishment is important in the Cloud computing landscape, how trust can act as a facilitator in this context to overcome the hindrances and what are the exact requirements for the trust and reputation models (or systems) in Cloud environments to support the consumers in establishing trust on Cloud providers.
