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We have several reasons to suspect that GsbN might act as a cofactor of EN for PC formation.
β-catenin is a multifunctional protein that, upon activation, can act as a cofactor for the TCF/LEF transcription factor complex to induce or enhance cell proliferation [4].
Magnesium seems to act as a cofactor for insulin receptor-associated tyrosine kinase activity [22], one among a large number of physiological actions of this element.
These observations may imply that nsp11 could act as a cofactor for nsp10 and the predicted cleavage site between nsp10 and nsp11 may be inefficient in vivo, thus resulting in the production of nsp10/nsp11 fusion protein in cells.
This hormone-protein complex can either bind directly to estrogen response elements (ERE's) in gene promoters, or it may act as a cofactor at non-ERE sites interacting with other DNA-binding elements such as AP-1 or c-Jun.
This hormone-protein complex can either bind directly to promoter estrogen response elements (EREs), or act as a cofactor at non-ERE sites through the interaction with other DNA-binding elements, such as AP-1, or c-Jun [5], [25] [26].
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Guanosine triphosphate acts as a cofactor to promote assembly of initial P element transposase-DNA synaptic complexes.
von der Lehr, N. et al. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.
The major circulating folate type, 5-methyl-THF, acts as a cofactor in methionine synthesis (Abbasi et al. 2018).
Generally, selenium acts as a cofactor and is present in some enzymatic structures called selenoproteins in animals.
Also, ascorbic acid acts as a cofactor of some enzymes to maintain their activity and a substrate for oxalate and tartrate biosynthesis (Benzie 1999).
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