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Efficacy exposure response relationships of the CCR5 antagonist maraviroc were evaluated across two phase III clinical trials.
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Fig. 9 Aligned patterns a across three phases and b between each two phases.
Interviews were conducted across two phases (<3 months apart) to ensure qualitative data was captured at different time intervals.
Cigarette smoke is a complex and dynamic aerosol consisting of at least 5,600 chemicals and toxicants found across two phases, the particulate (tar) and vapour phase [1].
Switching patterns between incorrect responses highlight that there exists a cohort who changes their responses across two phases but still remains incorrect.
In the PI case, the transition from a correct answer to an incorrect answer across two phases of voting generates a slide.
Additionally, tobacco smoke is a concentrated and complex mix of at least 5,600 chemicals and toxicants found across two phases, the particulate (tar) and vapour phase [ 14].
Across three phase II studies of gefitinib, only three partial responses and eight patients with stable disease lasting 6 months or longer were observed among a total of 113 patients [ 19- 21].
Across three phase 2 randomised studies where advanced breast cancer patients were treated with sorafenib in combination with chemotherapy (Baselga et al, 2012; Gradishar et al, 2013; Schwartzberg et al, 2013), the incidence of hand-foot syndrome, rash and diarrhea was 31 44, 2 4 and 3 6%, respectively.
Across five phase III trials of SC golimumab, 639 patients received placebo and 2226 received golimumab 50 mg (n=1249) and/or 100 mg (n=1501) up to wk 160 (patients may be included in more than one group because non-responders were allowed early escape); 1179 patients were treated for ≥156 weeks.
Fig. 10 Return patterns across three phases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com